Testosterone propionate is an oil based steroid with an propionate ester which will cause the steroid to be released from the injection site over the duration of a few days. This is different then the likes of testosterone enanthate which is much more slow acting compared to the propionate ester, which requires much more frequent injections to make sure blood concentrations remain stable. Injections every day, or every other day is the normal practice with testosterone propionate. The greater volume of injections needed when using testosterone propionate is not likeable for some users, either because of their circumstances, or because of the build up of scar tissue and therefore the need for more injection sites to rotate to avoid scar tissue build up. Testosterone propionate can be also a sore shot, and result in fever like symptoms for a couple of days. Some UG labs have starting producing 200mg/ml which has brought about some users experiencing very painful shots. Propionate is less soluble and therefore greater amounts of alcohol content will be present in the higher concentrations. Some users have found it more tolerable to mix the shot with another compound to dilute the mixture, and hopefully minimise the pain.
With having said the above, many users find testosterone propionate a very effective product. Testosterone is a very powerful steroid, and the propionate ester results in a situation in which blood concentrations can be controlled effectively, and cease of use will bring about a quicker decrease in blood concentrations for the user. This is what makes the product popular with female athletes.
Being a testosterone product we can expect the usual oestrogen related side effects from the testosterones tendency to convert to oestrogen. Many claim that the propionate is much more favourable compared to other testosterone esters as it brings about less side effects and a harder look. This should be taken with a pinch of a salt as the parent steroid is the same no matter the ester, all that is different is the release of the hormone from the depot. As said above however, if these side effects become unbearable for the user then the concentrations will drop quicker compared to that of other esters once the product is ceased, which can be much more favorable. Water retention can cause loss of definition due to the increase subcutaneous fluids, sudden increase in bodyweight, and related issues such as increased blood pressure and back and shin pumps are also common. The excess water bloat can become quite noticeable to other people too.
Gynecomstia can be a possible result of the excess oestrogen levels during and after the cycle. Gynecomstia is also sometime referred to as ‘gyne’ or ‘gyno’, and is the formation of breat tissue under the nipples. The first symptoms of gynecomstia if often sore or/and puffy nipples. If left untreated the gynecomstia could worsen and require surgery to correct. Ancillary drugs such as nolvedex and proviron may be implemented if a user is sensitive to such side effects, or develops them mid cycle. However, a better choice would be an anti-aromatase drug such as aromasin, arimidex or femara.
Biochemistry of Testosterone Propionate
Testosterone Propionate is simply Testosterone with the Propionate ester bound it’s chemical structure. The ‘Propionate’ is Propionic acid, but once bound to Testosterone it is known as an ester bond (or ester linkage). Propinoic acid is bonded to the 17-beta hydroxyl group on the Testosterone structure. Esterified anabolic steroids are more fat soluble, and release slowly from the injection site. The main reason for the increased half-life and release rate is because once Testosterone Propionate enters the bloodstream, enzymes work to break the bond between the ester and the testosterone, which takes a varying amount of time – depending on which ester is used. In the end enzymes remove the ester, and what is left is pure Testosterone which is free to do its work in the body. Testosterone alone with no ester bonded to it has a half-life of approximately 2 to 4 hours. When the Propionate ester is bonded to it, the half-life of Testosterone extends to about 4 and a half days.
Testosterone promotes nitrogen retention in the muscle – the more nitrogen the muscle holds the more protein it can store, and the bigger it gets. Testosterone also increases the body’s IGF-1 levels. IGF-1’s principal role is to coordinate growth and metabolism. IGF-I is highly dependent on growth hormone to complement it’s growth promoting activity.
Intended use of Testosterone Propionate
Testosterone Propionate has been vastly used for medical treatments shortly after its release in the 1930’s. Among other it was used for treatment for male androgen deficiency (andropause or hypogonadism), treatment for sexual dysfunction, and treatment for menopause, treatment for chronic dysfunctional uterine bleeding (menorrhagia), treatment for endometriosis. Later on testosterone would only be used for male patients.
Actual use of Testosterone Propionate
Testosterone Propionate is one of the most popular anabolic steroids even today – 80 years after it’s invention. It is widely used by bodybuilders and athletes for the purpose of physique and performance enhancement. Testosterone itself is considered the most natural and safest anabolic steroid a person can use. The Propionate ester is suggested for any first time steroid user.
How to use Testosterone Propionate?
The most common dosage for Testosterone Propionate is:
50 to 100mg every day
50 to 100mg every 2nd day
Every 3rd day should be the absolute minimum because that’s near the border of Propionate activity timespan.
Where to inject Testosterone Propionate
It can be injected into any muscle (if the muscle is big enough). The most popular being buttocks, shoulder or even triceps.
Testosterone propionate cycle compatibility, examples and duration
Test Prop goes very well in combination with Human Growth Hormone (4IU per day).
Popular stacks to complement Testosterone Propionate in cuting phase include oral anabolics like Winstrol (15-35 mg daily), Primobolan (50-150mg daily) or oxandrolone (15-30mg daily).
As with all testosterone types, Propionate is suited for bulking phase. For bulking it is usually combined with other strong androgens such as Dianabol, Anadrol, or Deca-Durabolin.
The cycle duration of Testosterone Propionate typically ranges from 8 to 16 weeks. At the end of the cycle, post testosterone treatment should be introduced, to jump start one’s natural testosterone production again.
Effects of Testosterone Propionate (desirable)
There are principally two desirable effects of Testosterone:
physical / athletic performance enhancement (endurance, strength, faster regeneration)
physique enhancement (muscle buildup, fat loss)
The rest of desirable testosterone effects that an individual might experience during the steroid cycle, include:
increase in collagen synthesis and bone mineral content. Collagen is the protein-based construction material for connective tissues throughout the body (the ligaments, tendons, cartilage, joints, and bones).
heightened self esteem
deeper (manly) voice
darkening and thickening of body hair
increase in levels of IGF-1 and MGF hormones (which also promote muscle growth)
increased hemoglobin (red blood cell count)
anti-catabolic effect on muscle tissues by way of acting as an anti-glucocorticoid
Side effects of Testosterone Propionate (and how to counter them)
Estrogenic side effects of Testosterone:
The primary side effects of Testosterone Propionate surround its ability to aromatize into Estrogen. Testosterone itself possesses a moderate level of Estrogenic activity – it holds a moderate affinity to bind to the aromatase enzyme (the enzyme responsible for the conversion of Testosterone into Estrogen). Because of that, a moderate level of aromatization is expected from Testosterone use. To counter this problem there are two solutions:
Selective Estrogen Receptor Modulators (SERMs) like Tamoxifen Citrate (Nolvadex) or Clomifene (brand names: Androxal, Clomid and Omifin) function by binding to the estrogen receptors – filling them and preventing actual estrogen from binding.
Aromatase Inhibitors (AIs) like Anastrozole (Arimidex) function by inhibiting the aromatase process and even lower the body’s own estrogen levels. Aromatise Inhibitors are far more effective than SERMs.
This side effect stems from increased estrogen levels and is countered by aromatase inhibitors (for example Anastrozole – Arimidex).
Increased blood pressure:
This is a result of water retention. It is countered by aromatase inhibitors.
Gynecomastia (aka Gyno / Bitch tits):
Gynecomastia is the abnormal development of breast tissue in males. Enlargement of the breast tissue is associated with increased estrogen levels. This is countered by Selective Estrogen Receptor Modulators or Aromatase Inhibitors.
Androgenic Side effects of Testosterone:
Testosterone androgenic side effects have more to do with the fact that Testosterone is converted into stronger and more potent androgen Dihydrotestosterone (DHT) by the 5-alpha reductase (5AR) enzyme.
The 5-alpha reductase enzyme is present in large amounts in certain tissues, such as the scalp, prostate, and the skin. When Testosterone reaches these tissues, it undergoes a high rate of reduction into its more potent androgenic metabolite DHT. It is DHT that is responsible for the greater severity of androgenic side effects.
This side effect is completely dependent on the individual’s genetic predisposition. If there are no bald men in your family, this will not be an issue for you. If male pattern baldness runs in your genes you will lose your hair anyway, but testosterone supplementation might speed up the process. This can be countered to some extent with Finasteride and the use of 2% Nizoral (Ketoconazole) shampoo.
Oily skin makes the hair more shiny. In other animals, males with more shiny fur are more desirable/healthier looking.
Oily skin in turn increases chances of pore clogging and formation of Acne. To some extent this can be countered by the use of Nizoral 2% shampoo, where its active ingredient Ketoconazole acts as a topical DHT blocker in skin and scalp, effectively reducing the probability of androgens triggering male pattern baldness as well as acne breakouts caused by increased oily skin. Acne are usually cleared with the discontinuation of steroids not very long after the discontinuation of the testosterone cycle.
Studies have shown clear associations between testosterone and aggression. Roid rage a type of impulse control – tendency to overreact to an event that normally wouldn’t set you off.
Shrinkage of testicles:
When external testosterone is supplemented our natural testosterone production is lowered. The testicles stop producing testosterone because there is plenty of it from external sournce. As a result they temporarily shrink. During the testosterone cycle there isn’t much we can do about testicular atrophy. Once the use of external testosterone comes to an end the natural testosterone production is gradually restored and testicles return to their full size. Steroid users speed up recovery by taking Clomiphene citrate (brand names: Androxal, Clomid and Omifin). HCG (Human chorionic Gonadotropin) is also used to rapidly restore natural testosterone production.
While supplementing with Testosterone, men often notice a hightened libido (sex drive). Likewise they notice a decrease of libido during the period when testosterone supplementation has ended and before natural testosterone production is restarted again (with clomiphene citrate or HCG).
Internet / forum rumors
It is rumored that Propionate is better for cutting and fat loss phases, and it supposedly causes less water retention than other esterified types of Testosterone. This is simply nonsense that has been passed on by people developing improper conclusions not based on scientific reasoning. Propionater (like any other ester bonded to Testosterone) is always broken off by enzymes in the body, after which 100% pure bio-identical Testosterone is left as a result. This Testosterone is then free to do its job in the body. The same occurs with any and all esterified forms of Testosterone. Therefore, the only possible difference that esterification causes to Testosterone’s effects is its half-life and rate of release. The esters only determine how much Testosterone is released into the bloodstream per given time frame.
Underground labs and their brand names
There are countless of underground producers of Testosterone Propionate. Some are proper labs who follow good manufacturing practices and have adequate equipment operated by knowledgable staff. Majority however are just “bathtub pharmacies” created in someone’s back room. They order raw materials from Asia, mix it together and repackage into vials – the end user can only hope it was done in sterile environment.
There are too many underground brands to list and new one are created more or less daily. Some of the names are:
TestP 100 by Big D Pharma, Prop 100 by Centrino Labs, Testosterone Phenyprop by Hulk Labs, Propionate by ARL, GP Test Prop 100 by Geneza, Testoprogen by United Hardcore Pharmaceuticals, Testodex Propionate 100 by Sciroxx, Viro-Prop by ROHM, Propionate 200 by Max Pro, Testabol Propionate by British Dragon EU, Testpronate 100 by Pro-chem, Lixus Prop by Lixus Labs, TestoRapid by Alpha Pharma, Testaplex P 100 by Axio, Propionat 100 by Dragon Pharma, Test P 100 by Optimal Labs, Veyron Pharma TP 1.0 by Veyron Pharma, Testos-P 100 by Pharmacom Labs, Testolic by Body Research, Propiobolic by Asia Pharma, Testabol Propionate by British Dragon, TestoPro 200 by Casablanca, TP 100 by P.E.A. Propitrex by Concentrex, Propionate 1000 by Muscle Pharma, Propioplex by Sarcoplex, Test-Prop 100by UniGen, and at least a hundred more.
History of Testosterone Propionate
Testosterone Propionate was invented in 1935. The ester was created to maximize the use of Testosterone itself (by prolonging its activity in the body). Shortly afterwards, Schering AG from Germany began manufacturing the first Testosterone Propionate product under the bradn name Testoviron, which is still a very popular brand name today. Testosterone Propionate was the first esterified type of Testosterone, and is the oldest/longest used esterified Testosterone. Propionate was the most widely used form of Testosterone in the world until the 1960s. It briefly existed in sublingual tablet form, but was discontinued during the 1980s.
Post Testosterone cycle treatment
Following the end of any cycle, a thorough and proper Post Cycle Therapy (PCT) program is always necessary, where Testosterone-stimulating ancillary compounds such as Nolvadex and/or HCG should be utilized in order to facilitate the normalization of the HPTA and endogenous Testosterone production as quickly as possible. PCT protocols and programs are usually run for the duration of 4 to 6 weeks after all anabolic steroids have cleared from the body following the end of the cycle. Failure to engage in a proper PCT program can result in permanent damage to the HPTA, whereby the individual produces insufficient/deficient levels of Testosterone (a medical condition known as hypogonadism), and medical treatment in the form of TRT (Testosterone Replacement Therapy) for life will be required.
Price of Testosterone Propionate
The prices vary depending on the quality and brand. Big pharma brands, prescribed through doctors are harder to come by and obviously the most expensive – up to tenfold increase compared to underground / black market Propionate.
On the black market (countless of online pharmacies) the Test Prop prices range from $45 to $90 per 10ml (100mg per ml) vial. The price difference is usually due to quality and purity of raw materials used, strength, and availability on the local market.
Good/Bad manufacturing practices of underground labs
Underground labs produce Testosterone Propionate in various ways. As is in human nature, some manufacturers will look to maximize their profit on the expense of the customer by using cheaper oils, less filtration due to lack of sophisticated equipment. To expedit filtration and dissolve lower quality raw materials, some labs use Guaiacol, Benzyl Salicylate, Octyl Salicylate, or Ethyl Oleate – which are harmful to the human body. By using these techniques they are able to have a cheaper product compared to higher quality competition.
Overview and History of Testosterone Propionate
Testosterone Propionate is one of the many esterified variants of Testosterone available. It is an injectable compound with a slower rate of release than un-esterified Testosterone, but a faster rate of release than all other esterified forms commonly available. This is due to the larger Propionate ester attached to the Testosterone molecule. This augments the release rate and half-life of Testosterone to that of a faster release than other common esterified variants, such as Testosterone Enanthate or Testosterone Propionate. The majority of Testosterone products that have been designed are single products that contain a single esterified form (such as this one), as opposed to Testosterone products which consist of a blend of several different esterified variants in the liquid (such as Sustanon 250, for example). Testosterone that is un-esterified holds a very short half-life, making its use very inconvenient and impractical (Testosterone suspension is one such Testosterone product that consists of pure un-esterified Testosterone, and does not have an ester bonded to its structure). The Propionate ester expands Testosterone’s half-life to that of 4.5 days. Testosterone itself is considered the most natural and safest anabolic steroid any individual can use, and it is easily the most versatile and flexible anabolic steroid in terms of how it can be utilized in cycles and for different purposes and goals.
Testosterone Propionate’s details and information were first published and released in 1935 as a result of various methods to determine the best possible manner of maximizing the uses of Testosterone itself, because as mentioned above, Testosterone un-esterified possesses a very short half-life. Shortly afterwards, Schering AG (located in Germany) began manufacturing and releasing on the market the very first Testosterone Propionate product under the trade name Testoviron, which is to this day still a very popular brand name. Testosterone Propionate was the very first esterified variant of Testosterone to ever be created, and is the oldest used esterified form of Testosterone dating back to the mid-1930s. Because of this, vast amounts of Testosterone Propionate was found among the prescription drug market in the United States, and was the most widely utilized form of Testosterone in the world until the 1960s. During the 1950s, Testosterone Propionate was but only one of 3 available anabolic steroids in existence (Testosterone suspension, Testosterone Propionate, and Methyltestosterone). Today there exist hundreds of anabolic steroid analogues. A little known fact as well is that Testosterone Propionate was also developed into a buccal and sublingual format that was not very popular and subsequently discontinued during the 1980s. Sublingual and buccal forms are tablets designed to be absorbed by the mucous membranes under the tongue (sublingual) as the tablet dissolves or by the mucous membranes between the surface of the gums and the cheek/lip.
Testosterone Propionate enjoyed a great amount of medical uses for various medical treatments shortly after its release. These included: treatment for male androgen deficiency (andropause or hypogonadism), treatment for sexual dysfunction, and treatment for menopause, treatment for chronic dysfunctional uterine bleeding (menorrhagia), treatment for endometriosis, and many additional countless medical applications. Eventually, as with all anabolic steroids, Testosterone Propionate’s approved medical treatments were eventually reduced by the FDA as a result of the increased control over the prescription drug market granted to the FDA by the United States government. Eventually, Testosterone would only be utilized for male patients.
Testosterone Propionate is a very popular anabolic steroid, and as such, enjoyed a very wide and common availability not only in the US market, but globally even today. This is due in large part, however, to the fact that for a long time the only Testosterone preparation available was Testosterone Propionate, and not because of preference. Later on, more convenient esterified forms of Testosterone were developed (Testosterone Enanthate and Testosterone Cypionate) which exhibited longer half-lives and windows of release, which therefore appealed to more individuals who preferred less frequent injections, which is what the later developed esterified Testosterone formats provided. Today Testosterone Propionate is still sold on the American prescription drug market, but its use is lower than it historically has been, and how much longer it will remain on the market is under question due to the more common use of other forms of Testosterone that have been developed that are more convenient and comfortable to use for most people.
Chemical Characteristics of Testosterone Propionate
As previously mentioned, Testosterone Propionate is simply Testosterone with the Propionate ester bound to the Testosterone chemical structure. Specifically ‘Propionate’ is Propionic acid, but once bound to Testosterone it is properly referred to in chemistry as an ester bond (or ester linkage). Propanoic acid is bonded to the 17-beta hydroxyl group on the Testosterone structure. Esterified anabolic steroids are more fat soluble, and release slowly from the injection site – however, this is not the main reason as to why esters extend the release rate of the anabolic steroid. The primary reason for the augmentation of its half-life and release rate is because once Testosterone Propionate enters the bloodstream, enzymes work to break the bond between the ester and the hormone, which takes a varying amount of time. The end result is that the ester is removed from the hormone by enzymes, and what is left is pure Testosterone that is free to do its work in the body. This process of enzymes cleaving off the ester from the Testosterone molecule is what is responsible for the slower release rates. Testosterone alone with no ester bonded to it possesses a half-life of approximately 2 – 4 hours. When the Propionate ester is attached to it, creating Testosterone Propionate, the half-life of Testosterone is now extended to 4.5 days, providing a slower release and activity of the hormone.
Properties of Testosterone Propionate
The properties of Testosterone Propionate are what any individual would expect from any other type of Testosterone preparation, with the exception of the differing release rates and half-life. Testosterone is what could be considered quite literally the original anabolic steroid, which is manufactured endogenously naturally in all humans and in the vast majority of animal species. Because of this, Testosterone is considered the safest anabolic steroid for use, as every individual’s body is already accustomed to the effects of Testosterone only to a lesser degree. Essentially, the use of Testosterone for the purpose of physique and performance enhancement is simply the supplementation of additional hormones – the act of inserting more of a hormone into the body that it already manufactures and uses.
Testosterone itself possesses a moderate level of Estrogenic activity, whereby it holds a moderate affinity to bind to the aromatase enzyme (the enzyme responsible for the conversion of Testosterone into Estrogen). Therefore, a moderate level of aromatization is to be expected with Testosterone use unless an aromatase inhibitor is utilized (such as Arimidex. Aromasin. and Letrozole ) to inhibit the aromatase enzyme and therefore render it unable to aromatize any Testosterone into Estrogen. Therefore, Testosterone serves as a preferable compound for bulking but can also be utilized for cutting and fat loss phases as well. At the end of the day, however, Testosterone of any type is required in any cycle of any anabolic steroid if at least for the maintenance of proper physiological function of Testosterone in the body during a period in which the endogenous production of Testosterone has been suppressed or shut down from the use of anabolic steroids. Testosterone itself is also a very strong anabolic compound, suitable even on its own for any purpose, and is in fact suggested as the very first and only anabolic steroid that should be utilized in all first-time and beginner cycles. Testosterone Propionate historically succumbed to the rumor among athletes and bodybuilders that it is better for cutting and fat loss phases, and many claimed that it provided less water retention than other esterified forms of Testosterone. This must be clarified as a large rumor and misunderstanding as a result of individuals developing improper conclusions not based on any proper scientific reasoning. As previously explained, the Propionate ester (or any ester affixed to Testosterone) is always broken off by enzymes in the body, after which 100% pure bio-identical Testosterone is left as a result. This Testosterone is then free to do its job in the body, and this occurs with all esterified forms of Testosterone. Therefore, the only possible augmentation that esterification has to Testosterone’s properties/effects are on its half-life and rate of release. If there is any difference in the actual reported experiences by different bodybuilders and athletes. it would most likely be extremely minimal, as the esters essentially only determine how much Testosterone is released into the bloodstream in any one given time frame.