PHARMACOLOGICAL ACTION In aplastic anaemias of various origins – both the idiopathic forms and those with exogenously damaged bone marrow – high doses of metenolone acetate may stimulate bone marrow function, particularly erythropoiesis. Metenolone acetate is a non-17alpha-alkylated anabolic steroid.
INDICATIONS Aplastic anaemias.
CONTRA-INDICATIONS Primobolan S is contra-indicated in pregnancy as the metenolone acetate contained in the preparation, like all anabolic agents, possesses some androgenic activity which may lead to signs of virilisation in the female newborn. Because of this androgenic activity, Primobolan S is also contra-indicated in patients with prostatic carcinoma, since such substances may aggravate the disease.
DOSAGE AND DIRECTIONS FOR USE The therapy may have to be continued for at least 3 months at a dosage of 2-3 mg/kg bodyweight per day, ie 4-6 tablets for a person weighing 50 kg. Since some patients only respond after several months, treatment must not be stopped too soon. After improvement of the clinical picture treatment should, as a general rule, be continued for a further few weeks. Deterioration of the blood count after discontinuation of therapy may be reversed by renewed administration of Primobolan S.
SIDE EFFECTS AND SPECIAL PRECAUTIONS In female patients, signs of virilisation (acne, hirsutism, hoarseness, possibly irreversible deepening of the voice) must be reckoned with; in sexually mature women menstrual irregularities may occur. In adult males, spermatogenesis may be inhibited, in boys there may be signs of premature puberty. Non-adult patients should be monitored for accelerated bone maturation by X-ray. Impairment of liver function is less frequent than with a 17alpha-alkylated anabolic steroid. In men, regular examinations of the prostate should be carried out prophylactically to exclude a malignant tumour.
Primobolan is an almost pure anabolic with an extremely low androgenic component. The ratio of the anabolic to the androgenic effect is indeed very favorable but, since the overall anabolic effect is only moderately strong, Primobolan tablets have only a limited effect in building up muscle mass and strength. With Primobolan neither fast weight gains nor explosive strength gains occur. Primobolan is therefore mostly taken over a prolonged period since it gives only a slow but also a high quality muscle gain, which mostly remains after use of the compound is discontinued. An effective daily dose observed in athletes is in the range of 50-150 mg so that the 25 mg tablets are preferred to the 5 mg tablets. As for the recommended dose, the athlete obtains interesting information from the German package insert by Schering AG for their compound Primobolan S: “Unless otherwise prescribed the following guidelines apply: The dosage should be I – 1,5 mg per pound of body weight/day, that is 4-6 tablets for 100 pound of bodyweight.” A bodybuilder weighing 100 kg should therefore take 200-300 mg daily, which would correspond to a dosage of eight to twelve 25 mg tablets per day. We believe that this dosage is too high; however, this example shows that a fairly large dosage of the oral acetate form is necessary. The reason is that the Primobolan acetate tablets are not I 7-alpha alkylated and, during the first pass in the liver, a large part of the substance is destroyed and thus deactivated leaving only a much smaller quantity of the substance to get into the blood.
If Primobolan is the only steroid that is taken, then with respect to strength and muscle buildup, it will usually lead to success in women and steroid novices. This, however, changes greatly when Primobolan is combined with steroids that are moderately too highly androgenic but which themselves do not aromatize or retain water. In such an environment the anabolic effect of Primobolan can develop to its optimum. Masteron. Parabolan. Equipoise. and Winstrol. are particularly suitable. The effect can be optimized by the additional intake of Oxandrolone. Steroid novices and the less advanced achieve a good strength and muscle gain by taking 50-100 mg Primobolan S/day and 150 mg Winstrol Depor/week, without retaining water. Even competing athletes report good quality gains with continuously “harder” muscles when taking 150 mg Primobolan S/day and 50 mg Winstrol Depor every two days, as well as 76 mg of Parabolan every two days.
The main uses of the Primobolan tablets, however, are in the preparation for a competition and in use by women. Since the acetate form does not aromatize into estrogens and does not cause water retention, the use of Primobolan during competitions is widespread. Acetate tablets are special in that they actively help burn fat. The Primobolan acetate tablets, however, must never be taken as the only steroid during a diet since, due to its extremely low androgenic effect, significant losses in muscle and strength can occur and there is a risk of over training. The above-mentioned common steroid combinations are extremely effective when combined with a suitable diet during the preparation for a competition. Due to the fact that the acetate tablets burn fat but, at the same time, that in large part they are already deactivated in the liver, it would be most efficient to apply the compound locally, bringing the substance directly into the blood through the skin in the areas with undesired fat deposits. At first this seems a little adventurous, but it is possible with the DMSO compound. Dimethyl sulfoxide (DMSO) is one of few substances which are fully absorbed through the skin and distributed through the body It is included in many ointments and gels which are used to treat sport injuries, contusions, swellings, and effusions in order to transport the casing substance through the skin. In addition, DMSO makes the skin permeable to other substances.
Finely grind up one 25 mg Primobolan tablet with the grip of a knife on your kitchen board, mix it with half a teaspoon of DMSO gel and then apply a thin layer to your skin. It is important that you only apply it; do not rub it in. One or two applications are usually enough. Another way to avoid the liver and consequent destruction of the substance is to grind up the Primobolan tablets in a mortar and consume them together with heated vitamin E oil. The Primobolan/vitamin E mixture reaches the blood similar to Andriol that is the absorption occurs through the lymph system and the solution does not reach the liver through the portal vessel.
Since the Primobolan tablets are not I 7-alpha alkylated but have a 17-beta hydroxy group they are almost non-toxic to the liver. In a high dosage, however, they can influence the liver values resulting in higher biliburin, GPT, GOT, and alkaline phosphatase. Primobolan generally does not cause any significant side effects since it does not aromatize, does not cause water retention, is not I 7-alpha alkylated, and is only slightly androgenic. Blood pressure, liver values, cholesterol level, HDL and LDL values usually remain unaffected, making Primobolan well liked by health-conscious older athletes. Primo is often an “entry drug” for novice users and, due to its rare side effects, encourages many steroid users to switch to “harder” stuff such as Dianabol. Anadrol 50. and testosterone. Since Primobolan is a precursor of dihydrotestosterone it can accelerate hair loss if such a predisposition exists.